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Filtered Search Results
Medchemexpress LLC VE-821 | 1232410-49-9 | 99.7% | 368.41 | 100 MG
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VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 values of 13 nM/26 nM. It exhibits excellent selectivity for ATR, demonstrating minimal cross-reactivity with related PIKKs like ATM, DNA-PK, mTOR, and PI3Kγ. This compound enhances the sensitivity of pancreatic cancer cells (PSN-1, MiaPaCa-2, and primary PancM) to radiation and Gemcitabine under both normoxic and hypoxic conditions. ATR inhibition by VE-821 also leads to the inhibition of radiation-induced G2/M arrest in cancer cells.
- Potent ATP-competitive inhibitor of ATR (Ki/IC50 of 13 nM/26 nM)
- Exhibits excellent selectivity for ATR with minimal cross-reactivity against related PIKKs
- Enhances sensitivity of pancreatic cancer cells to radiation and Gemcitabine
- Inhibits radiation-induced G2/M arrest in cancer cells
- Inhibits phosphorylation of Chk1 (Ser 345) after specific treatments
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Apexbio Technology LLC I-BET-762 1260907-17-2 50mg
I-BET-762 (CAS 1260907-17-2) is a small-molecule inhibitor targeting the BET (bromodomain and extra-terminal) family of proteins It acts by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains thereby displacing acetylated histones with an IC50 ranging from 32 5 to 42 5 nM and a dissociation constant (Kd) between 50 5 and 61 3 nM I-BET-762 displays high selectivity exhibiting no interaction with non-BET bromodomain-containing proteins In cellular studies it downregulates LPS-induced gene expression resulting in reduced production of pro-inflammatory cytokines and chemokines In vivo models demonstrate its potential to attenuate features of established inflammatory disease supporting its utility in epigenetic and inflammation-related research
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Medchemexpress LLC Bpin-Cyclohexene-COOEt | 1049004-32-1 | 280.17 | 25 G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Bpin-Cyclohexene-COOEt is a PROTAC linker from the PEG class, primarily used in the synthesis of PROTAC molecules. This chemical appears as a colorless to light yellow liquid, suitable for laboratory research and the manufacture of substances. It is important to note that this product is intended for research purposes only and has not been validated for medical applications.
- PROTAC linker for synthesizing PROTAC molecules
- Clear to light yellow liquid appearance
- Purity greater than or equal to 97.0%
- Molecular weight of 280.17
- Store pure form at -20°C for up to 3 years
- Unstable in solutions; use freshly prepared solutions
- Stable under recommended storage conditions
- Intended for research use only
- Not validated for medical applications
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Cayman Chemical cis-Petroselinic Acid, Purity: ≥98%, CAS: 593-39-5, 500 mg
A monounsaturated fatty acid and isomer of oleic acid; major component of plant lipids; rats fed a diet containing it have a reduction in arachidonic acid levels and an increase in linoleic acid levels in the heart, liver, and blood; has been used in a composite membrane to study plant uptake; has been used in the synthesis of new biosurfactants (sophorolipids)
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Medchemexpress LLC Butyne-DOTA-tris(t-butyl ester) | 2125661-54-1 | 98.5% | 623.82 g/mol | C32H57N5O7 | 25 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Butyne-DOTA-tris(t-butyl ester) is a DOTA-based bifunctional chelator designed for conjugation of peptides and radionuclides. It is intended for radiopharmaceutical development and tumor pre-targeting workflows, supplied as a white to off-white solid.
- Bifunctional DOTA derivative for peptide and radionuclide conjugation.
- Supports tumor pre-targeting and radiopharmaceutical research.
- High purity suitable for analytical and synthetic applications (98.5%).
- Molecular weight 623.82 g/mol; formula C32H57N5O7.
- Available in small research pack sizes, including 25 MG.
- Provided with SDS and documentation for safe handling.
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Selleck Chemical LLC VE-821
VE-821(ATR inhibitor IV) is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays shows inhibition of H2AX phosphorylation minimal activity against PIKKs ATM DNA-PK mTOR and PI3K
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eMolecules 1632-16-2 | 2-ETHYL-1-HEXENE | AstaTech | MFCD00027242 | 112.216 | C8H16 | 95.000 | CCCCC(=C)CC | 1g | 718058557
2-ETHYL-1-HEXENE | AstaTech | 1632-16-2 | MFCD00027242 | 112.216 | C8H16 | 95.000 | CCCCC(=C)CC | 1g | 718058557
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Selleck Chemical LLC VE-821
VE-821(ATR inhibitor IV) is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays shows inhibition of H2AX phosphorylation minimal activity against PIKKs ATM DNA-PK mTOR and PI3K
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cambridge Isotope Laboratories 1-Octene (1 1-D2 98%) 0 5 g
1-Octene (1 1-D2 98%) 0 5 g
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Aqua Solutions 1-OCTENE IN SOLVENT ISOPAR E
Aqua Solutions 5% w/w 1-Octene in Solvent (Isopar E) (600G)
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TARGETMOL CHEMICALS INC CWHM-1552 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains the IC50s are 51 nM and 53 nM. purity: 100%
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Aobchem Phenylmethyl 3-cyclopentene-1-carboxylate | 95% | CAS 130762-09-3 | C13H14O2 | 1g
Phenylmethyl 3-cyclopentene-1-carboxylate | 95% | CAS 130762-09-3 | C13H14O2 | 1g
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Aobchem Phenylmethyl 3-cyclopentene-1-carboxylate | 95% | CAS 130762-09-3 | C13H14O2 | 250mg
Phenylmethyl 3-cyclopentene-1-carboxylate | 95% | CAS 130762-09-3 | C13H14O2 | 250mg
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Sigma Aldrich Fine Chemicals Biosciences trans-2-Octene | 13389-42-9 | MFCD00009532 | 10g
trans-2-Octene | 97% | 112.21 | 13389-42-9 | MFCD00009532 | 10g
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Medchemexpress LLC Tau protein (592-597), human (TFA) | 2703746-44-3 | 95.2% | 868.94 | 25 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Tau protein (592-597), human TFA, is a peptide fragment of human Tau protein. The dysfunction of Tau protein is involved in neurodegeneration and dementia, making this compound relevant for neurodegenerative disease research.
- Purity: 95.2%
- Molecular weight: 868.94
- Formula: C36H63F3N10O11
- Appearance: White to off-white solid
- Sequence: Ac-Val-Gln-Ile-Ile-Asn-Lys-NH2 (Ac-VQIINK-NH2)
- Solubility in H2O: ≥ 2 mg/mL (2.30 mM)
- Recommended storage for powder: -80°C for 2 years, -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month (sealed, away from moisture)
- For research use only
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